‘Click peptide’: a novel ‘O‐acyl isopeptide method’ for peptide synthesis and chemical biology‐oriented synthesis of amyloid β peptide analogues
Identifieur interne : 002D78 ( Main/Exploration ); précédent : 002D77; suivant : 002D79‘Click peptide’: a novel ‘O‐acyl isopeptide method’ for peptide synthesis and chemical biology‐oriented synthesis of amyloid β peptide analogues
Auteurs : Youhei Sohma ; Atsuhiko Taniguchi ; Taku Yoshiya ; Yousuke Chiyomori ; Fukue Fukao ; Setsuko Nakamura ; Mariusz Skwarczynski ; Takuma Okada [Japon] ; Keisuke Ikeda [Japon] ; Yoshio Hayashi ; Tooru Kimura ; Shun Hirota ; Katsumi Matsuzaki [Japon] ; Yoshiaki Kiso [Japon]Source :
- Journal of Peptide Science [ 1075-2617 ] ; 2006-12.
English descriptors
- Teeft :
- Acyl, Amyloid, Amyloid peptide, Aspartic protease inhibitors, Chem, Chemical synthesis, Click, Click peptide, Copyright, European peptide society, Hayashi, Inhibitor, Intramolecular, Intramolecular acyl migration, Intramolecular acyl migration reaction, Isodipeptide unit, Isopeptide, Isopeptide method, Isopeptide structure, John wiley sons, Kimura, Kiso, Lett, Native amide bond, Native peptides, Pept, Peptide, Peptide chemistry, Peptide derivatives, Peptide synthesis, Physiological conditions, Prodrugs, Protease, Protease inhibitors, Protective group, Sohma, Tetrahedron lett.
Abstract
After over a decade of studies on aspartic protease inhibitors and water‐soluble prodrugs, we have been developing a novel method, since 2003, called ‘O‐acyl isopeptide method’, for the synthesis of peptides containing difficult sequences. With our recent discoveries of ‘O‐acyl isodipeptide unit’ and the ‘racemization‐free segment condensation method’, this method has further evolved as a general synthetic method for peptides. Moreover, ‘Click Peptide’, which could be a powerful tool for identifying the pathological functions of amyloid β peptides in Alzheimer's disease, represents a valuable use of the isopeptide method in Chemical Biology‐oriented research. Copyright © 2006 European Peptide Society and John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/psc.817
Affiliations:
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607‐8412</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Peptide Science</title><title level="j" type="sub">10th Naples Workshop on Bioactive Peptides</title><title level="j" type="alt">JOURNAL OF PEPTIDE SCIENCE</title><idno type="ISSN">1075-2617</idno><idno type="eISSN">1099-1387</idno><imprint><biblScope unit="vol">12</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="823">823</biblScope><biblScope unit="page" to="828">828</biblScope><biblScope unit="page-count">6</biblScope><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2006-12">2006-12</date></imprint><idno type="ISSN">1075-2617</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1075-2617</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acyl</term><term>Amyloid</term><term>Amyloid peptide</term><term>Aspartic protease inhibitors</term><term>Chem</term><term>Chemical synthesis</term><term>Click</term><term>Click peptide</term><term>Copyright</term><term>European peptide society</term><term>Hayashi</term><term>Inhibitor</term><term>Intramolecular</term><term>Intramolecular acyl migration</term><term>Intramolecular acyl migration reaction</term><term>Isodipeptide unit</term><term>Isopeptide</term><term>Isopeptide method</term><term>Isopeptide structure</term><term>John wiley sons</term><term>Kimura</term><term>Kiso</term><term>Lett</term><term>Native amide bond</term><term>Native peptides</term><term>Pept</term><term>Peptide</term><term>Peptide chemistry</term><term>Peptide derivatives</term><term>Peptide synthesis</term><term>Physiological conditions</term><term>Prodrugs</term><term>Protease</term><term>Protease inhibitors</term><term>Protective group</term><term>Sohma</term><term>Tetrahedron lett</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">After over a decade of studies on aspartic protease inhibitors and water‐soluble prodrugs, we have been developing a novel method, since 2003, called ‘O‐acyl isopeptide method’, for the synthesis of peptides containing difficult sequences. With our recent discoveries of ‘O‐acyl isodipeptide unit’ and the ‘racemization‐free segment condensation method’, this method has further evolved as a general synthetic method for peptides. Moreover, ‘Click Peptide’, which could be a powerful tool for identifying the pathological functions of amyloid β peptides in Alzheimer's disease, represents a valuable use of the isopeptide method in Chemical Biology‐oriented research. Copyright © 2006 European Peptide Society and John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région du Kansai</li></region><settlement><li>Kyoto</li></settlement><orgName><li>Université de Kyoto</li></orgName></list><tree><noCountry><name sortKey="Chiyomori, Yousuke" sort="Chiyomori, Yousuke" uniqKey="Chiyomori Y" first="Yousuke" last="Chiyomori">Yousuke Chiyomori</name><name sortKey="Fukao, Fukue" sort="Fukao, Fukue" uniqKey="Fukao F" first="Fukue" last="Fukao">Fukue Fukao</name><name sortKey="Hayashi, Yoshio" sort="Hayashi, Yoshio" uniqKey="Hayashi Y" first="Yoshio" last="Hayashi">Yoshio Hayashi</name><name sortKey="Hirota, Shun" sort="Hirota, Shun" uniqKey="Hirota S" first="Shun" last="Hirota">Shun Hirota</name><name sortKey="Kimura, Tooru" sort="Kimura, Tooru" uniqKey="Kimura T" first="Tooru" last="Kimura">Tooru Kimura</name><name sortKey="Nakamura, Setsuko" sort="Nakamura, Setsuko" uniqKey="Nakamura S" first="Setsuko" last="Nakamura">Setsuko Nakamura</name><name sortKey="Skwarczynski, Mariusz" sort="Skwarczynski, Mariusz" uniqKey="Skwarczynski M" first="Mariusz" last="Skwarczynski">Mariusz Skwarczynski</name><name sortKey="Sohma, Youhei" sort="Sohma, Youhei" uniqKey="Sohma Y" first="Youhei" last="Sohma">Youhei Sohma</name><name sortKey="Taniguchi, Atsuhiko" sort="Taniguchi, Atsuhiko" uniqKey="Taniguchi A" first="Atsuhiko" last="Taniguchi">Atsuhiko Taniguchi</name><name sortKey="Yoshiya, Taku" sort="Yoshiya, Taku" uniqKey="Yoshiya T" first="Taku" last="Yoshiya">Taku Yoshiya</name></noCountry><country name="Japon"><region name="Région du Kansai"><name sortKey="Okada, Takuma" sort="Okada, Takuma" uniqKey="Okada T" first="Takuma" last="Okada">Takuma Okada</name></region><name sortKey="Ikeda, Keisuke" sort="Ikeda, Keisuke" uniqKey="Ikeda K" first="Keisuke" last="Ikeda">Keisuke Ikeda</name><name sortKey="Kiso, Yoshiaki" sort="Kiso, Yoshiaki" uniqKey="Kiso Y" first="Yoshiaki" last="Kiso">Yoshiaki Kiso</name><name sortKey="Kiso, Yoshiaki" sort="Kiso, Yoshiaki" uniqKey="Kiso Y" first="Yoshiaki" last="Kiso">Yoshiaki Kiso</name><name sortKey="Matsuzaki, Katsumi" sort="Matsuzaki, Katsumi" uniqKey="Matsuzaki K" first="Katsumi" last="Matsuzaki">Katsumi Matsuzaki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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